Oxygen Dissociation Curve Flashcards

The oxygen dissociation curve is a graph showing the relationship between the partial pressure of oxygen (pO₂) and the percentage saturation of hemoglobin (Hb) with oxygen.

Cooperative binding: When one O₂ binds to hemoglobin, it increases hemoglobin’s affinity for the next O₂ molecule. This causes the curve to rise slowly at first, then steeply, and finally plateau.

pO2 = 20-40 mmHg Saturation = 25-50% O2 released from Hgb

pO2 = 40-60 mmHg Saturation = 60-85% Moderate binding

pO2 = 100 mmHg Saturation = 98% Almost full saturation

Right Shift = Releae of O2 more easily Right =Release 🔼 CO2, Acidity, 2,3 DPG, Exercise, Temperature

Left = Loads O2 more tightly 🔽 CO2 = Less oxygen delivery 🔼 pH = Tigher binding 🔽2, 3 DPG & Temperature Fetal HB = Higher O2 affinity

HbF curve is left shifted compared to adult Ensures fetus can grab O2 from maternal blood

S-Curve no change 🔽 O2 content

Left shift (CO binds Hgb strongly, reducing O2 delivery

Right shift to enhance tissue oxygenation